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    CHEMICAL DETECTION DEVICE HAVING MULTIPLE FLOW CHANNELS
    2.
    发明申请
    CHEMICAL DETECTION DEVICE HAVING MULTIPLE FLOW CHANNELS 审中-公开

    公开(公告)号：US20180224393A1

    公开(公告)日：2018-08-09

    申请号：US15943668

    申请日：2018-04-02

    Applicant: Life Technologies Corporation

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M. LEVINE ,  Mark James MILGREW

    IPC: G01N27/414 ,  H04N5/374 ,  G01R29/26 ,  C12Q1/6869 ,  H01L29/66 ,  H01L27/146 ,  G01N33/00 ,  G01J1/46

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    Chemical Detection Device Having Multiple Flow Channels
    4.
    发明申请
    Chemical Detection Device Having Multiple Flow Channels 审中-公开
    具有多个流通道的化学检测装置

    公开(公告)号：US20150241387A1

    公开(公告)日：2015-08-27

    申请号：US14597507

    申请日：2015-01-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M. LEVINE ,  Mark James MILGREW

    IPC: G01N27/414

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    Abstract translation: 所描述的实施例可以提供化学检测电路，其可以包括在第一侧的多个第一输出电路和在化学检测电路的第二侧的多个第二输出电路。 化学检测电路还可以包括多个像素瓦片，每个瓷砖分别放置在相应的第一和第二输出电路对之间。 每个瓦片可以包括四个像素象限。 每个象限可以具有与第二列交错的指定的第一列的列。 每个第一列可以耦合到第一和第二象限中的相应的第一输出电路，以及耦合到第三和第四象限中的相应的第二输出电路。 每个第二列可以耦合到第一和第二象限中的相应的第二输出电路，以及耦合到第三和第四象限中的相应的第一输出电路。

    Semiconductor-Based Chemical Detection Device
    5.
    发明申请
    Semiconductor-Based Chemical Detection Device 有权

    公开(公告)号：US20210172907A1

    公开(公告)日：2021-06-10

    申请号：US17064948

    申请日：2020-10-07

    Applicant: Life Technologies Corporation

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M LEVINE ,  Mark James MILGREW

    IPC: G01N27/414 ,  H01L27/146 ,  H04N5/374 ,  G01R29/26 ,  H01L29/66 ,  G01N33/00 ,  C12Q1/6869

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    CAPACITIVE CHARGE PUMP
    6.
    发明申请
    CAPACITIVE CHARGE PUMP 审中-公开
    电容充电泵

    公开(公告)号：US20140361781A1

    公开(公告)日：2014-12-11

    申请号：US14465251

    申请日：2014-08-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Peter M. LEVINE ,  Mark James MILGREW ,  Todd REARICK

    IPC: G01N27/414

    Abstract: One or more charge pumps may be used to amplify the output voltage from a chemically-sensitive pixel that comprises one or more transistors. A charge pump may include a number of track stage switches, a number of boost phase switches and a number of capacitors. The capacitors are in parallel during the track phase and in series during the boost phase, and the total capacitance is divided during the boost phase while the total charge remains fixed. Consequently, the output voltage is pushed up.

    Abstract translation: 可以使用一个或多个电荷泵来放大来自包含一个或多个晶体管的化学敏感像素的输出电压。 电荷泵可以包括多个轨道平台开关，多个升压相位开关和多个电容器。 电容器在磁道相位期间并联并且在升压阶段期间串联，并且总电容在升压阶段被分压，而总电荷保持固定。 因此，输出电压被上推。

    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    8.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开

    公开(公告)号：US20160168635A1

    公开(公告)日：2016-06-16

    申请号：US15051084

    申请日：2016-02-23

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan M. ROTHBERG ,  James BUSTILLO ,  Mark James MILGREW ,  Jonathan SCHULTZ ,  David MARRAN ,  Todd REARICK ,  Kim L. JOHNSON

    IPC: C12Q1/68 ,  G01N27/414

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    10.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开

    公开(公告)号：US20160011145A1

    公开(公告)日：2016-01-14

    申请号：US14863718

    申请日：2015-09-24

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan M. ROTHBERG ,  James BUSTILLO ,  Mark James MILGREW ,  Jonathan SCHULTZ ,  David MARRAN ,  Todd REARICK ,  Kim L. JOHNSON

    IPC: G01N27/414 ,  C12Q1/68

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

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