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公开(公告)号：US20230331829A1
公开(公告)日：2023-10-19
申请号：US18089393
申请日：2022-12-27
Inventor： Jin Woo KIM , Eun Jung LEE
CPC classification number: C07K16/18 , C12N15/86 , C07K2317/565 , C07K2317/24 , C07K2317/622 , C12N2750/14143
Abstract: The present disclosure relates to a PROX1 (Prospero homeobox protein 1) protein binding molecule. More specifically, the binding molecule of the present disclosure relates to a binding molecule having excellent binding ability to the PROX1 protein and having an excellent neutralizing effect on the PROX1 protein, and it is very useful for diagnosis, prevention or treatment of retinal neurodegenerative diseases.
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公开(公告)号：US20210163554A1
公开(公告)日：2021-06-03
申请号：US17110924
申请日：2020-12-03
Inventor： Jin Woo KIM , Eun Jung LEE
IPC: C07K14/47
Abstract: Disclosed is a method for regulating the extracellular secretion ability of a homeoprotein and a homeoprotein variant having regulated extracellular secretion ability using the same, and more particularly, a method for increasing or decreasing the extracellular secretion ability through the increase or decrease in hydrophobicity of an amino acid sequence among homeodomain external amino acid sequences, or a homeoprotein whose extracellular secretion ability is increased or decreased through the increase or decrease in hydrophobicity of the homeodomain external amino acid sequence.
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公开(公告)号：US20220243242A1
公开(公告)日：2022-08-04
申请号：US17586234
申请日：2022-01-27
Inventor： Jin Woo KIM , Jun Woo PARK
IPC: C12P21/02
Abstract: A composition for enhancing the production of a homeoprotein includes an inhibitor of lysosomal function. A method for enhancing the production of a homeoprotein, includes treating cells with an inhibitor of lysosomal function, a method for producing an animal cell line continuously expressing a homeoprotein and a method for mass-producing a homeoprotein using the animal cell line.
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