公开(公告)号：US20220268672A1

公开(公告)日：2022-08-25

申请号：US17675808

申请日：2022-02-18

Applicant: Korea Advanced Institute Of Science And Technology

Inventor： Jae-Byum CHANG ,  In CHO ,  Chan E. PARK ,  Jueun SIM ,  Young-Gyu YOON

IPC: G01N1/30 ,  G06T7/33

Abstract: Disclosed are three-dimensional image registration via dense staining and a super-resolution multiplexed imaging method using the same. The three-dimensional image registration includes: placing at least one fiducial marker in an internal structure of a living tissue via dense staining; obtaining a plurality of images by repeatedly imaging the living tissue while replacing a fluorescent label attached to at least one target molecule within the living tissue where the fiducial marker is placed; and registering the images using the fiducial marker as a reference to obtain a final image of the target molecule.

公开(公告)号：US20220126523A1

公开(公告)日：2022-04-28

申请号：US17508741

申请日：2021-10-22

Applicant: Korea Advanced Institute of Science and Technology

Inventor： JaeByum CHANG ,  Eunseok HEO ,  In CHO

IPC: B29C64/40 ,  B29C64/30 ,  B29C64/106 ,  B29C64/245

Abstract: Various embodiments provide a method of manufacturing a high-resolution structure using a size-tunable hydrogel. According to various embodiments, a basic structure may be fabricated. A temporary structure made of a hydrogel may be fabricated by applying a hydrogel to the basic structure. The temporary structure may shrink by dehydrating the hydrogel. This process may be repeated to fabricate smaller structures. The final structure may be fabricated using the temporary structure or the basic structure.