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公开(公告)号：US20210177764A1
公开(公告)日：2021-06-17
申请号：US17047174
申请日：2019-04-11
发明人： Won Ho Kang , Won Tae Jung , Jung Hoon Kang , Youn Woong Choi
IPC分类号： A61K9/19 , A61K31/675 , A61K47/26
摘要： The present invention relates to a method for preparing a lyophilized cyclophosphamide composition, wherein 99% or more of the finally prepared lyophilized cyclophosphamide composition is reconstituted within 15 seconds when water for pharmaceutical use is injected thereinto at a ratio of 50 mL per 1 g of anhydrous cyclophosphamide, comprising a step of dissolving D-mannitol or lactose, as a lyoprotectant, and cyclophosphamide in a water solvent in a selected reaction vessel; and a lyophilized cyclophosphamide composition for injection prepared thereof.
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公开(公告)号：US20180104264A1
公开(公告)日：2018-04-19
申请号：US15385033
申请日：2016-12-20
发明人： Won Ho Kang , Won Tae Jung , Young Ho Lee , Jung Hoon Kang , Byuck Ho Kim
CPC分类号： A61K31/675 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K47/02 , A61K47/26
摘要： The present invention relates to a method for preparing a lyophilized composition with improved stability and solubility, which comprises dissolving cyclophosphamide, sodium chloride, and D-mannitol in water as a solvent in a reaction container at 40° C. to 70° C., and a lyophilized cyclophosphamide composition for injection prepared according to the method.
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公开(公告)号：US12053574B2
公开(公告)日：2024-08-06
申请号：US16626410
申请日：2017-06-29
发明人： Won Ho Kang , Youn Woong Choi , Dae Chul Ha , Seung Jin Yang , Gweon Hee Yu , Kyu Yeol Nam , Kyu Chul Jang
CPC分类号： A61M15/0005 , A61K9/0075 , A61K47/26 , A61K47/36
摘要： The present invention relates to a dry powder inhaler. The dry powder inhaler includes an inhaler housing, a drug container configured to be provided in the inhaler housing and accommodate the dry powder drug, a drug inlet configured to be disposed above the drug container and through which the dry powder drug is inhaled, and a mesh network configured to be installed on a path of the drug inlet and have a mesh part for collision with the dry powder drug formed therein.
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公开(公告)号：US11707434B2
公开(公告)日：2023-07-25
申请号：US17047174
申请日：2019-04-11
发明人： Won Ho Kang , Won Tae Jung , Jung Hoon Kang , Youn Woong Choi
IPC分类号： A61K9/19 , A61K31/675 , A61K47/26
CPC分类号： A61K9/19 , A61K31/675 , A61K47/26
摘要： The present invention relates to a method for preparing a lyophilized cyclophosphamide composition, wherein 99% or more of the finally prepared lyophilized cyclophosphamide composition is reconstituted within 15 seconds when water for pharmaceutical use is injected thereinto at a ratio of 50 mL per 1 g of anhydrous cyclophosphamide, comprising a step of dissolving D-mannitol or lactose, as a lyoprotectant, and cyclophosphamide in a water solvent in a selected reaction vessel; and a lyophilized cyclophosphamide composition for injection prepared thereof.
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