公开(公告)号：US09783837B2

公开(公告)日：2017-10-10

申请号：US14735456

申请日：2015-06-10

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hae Shin Lee ,  Seon Ki Hong ,  Joseph Paul Park

IPC: C12P13/00 ,  C08J5/18 ,  C08K3/08 ,  C08L79/02 ,  C12P13/02 ,  C12P19/26

CPC classification number: C12P13/001 ,  C08J5/18 ,  C08J2379/02 ,  C08K3/08 ,  C08K2003/0806 ,  C08K2201/013 ,  C08L79/02 ,  C12P13/02 ,  C12P19/26

Abstract: The present invention relates to a method for preparing a double-sided film containing the step of 5 forming a film in the interface between air and the mixture of a polymer comprising amine group (—NH) and a compound containing phenol or catechol by exposing the mixture on the air. Particularly, the double-sided film of the present invention is a separation membrane 10 that can separate the interface of liquid phase and gas phase and at the same time can be used as a biomaterial such as a haemostatic and also an waterproof agent. When the film is prepared in a moderate condition by using an enzyme, the film can include proteins and 15 cells, resulting in the multi-functional versatility film that can be useful as a biocatalyst. The versatility film of the present invention, thus, is not expensive and the production method thereof is simple and eco-friendly.

公开(公告)号：US20170252319A1

公开(公告)日：2017-09-07

申请号：US15449011

申请日：2017-03-03

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Haeshin Lee ,  WhuiSu Shim ,  Mihyun Lee ,  Joseph Paul Park

IPC: A61K31/353 ,  A61K47/10

CPC classification number: A61K31/353 ,  A61K9/08 ,  A61K9/146 ,  A61K47/10

Abstract: The present invention relates to a flavonoid-poly(ethylene glycol) complex comprising flavonoid compounds and poly(ethylene glycol) and a preparation method of the same. The flavonoid-poly(ethylene glycol) complex of the invention displays a significantly improved solubility of flavonoid which is usually insoluble in an aqueous solution and contains flavonoid compounds distributed evenly in the complex so that the complex of the invention can be effectively used for the establishment of a method for enhancing solubility of flavonoid in an aqueous solution and a method for enhancing bioavailability of flavonoid.