公开(公告)号：US20230355513A1

公开(公告)日：2023-11-09

申请号：US18219956

申请日：2023-07-10

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sangyong JON ,  Afia Tasnim RAHMAN ,  Chang-Hee WHANG

IPC: A61K9/00 ,  A61P1/00 ,  C08B37/08 ,  A61K31/409 ,  A61K47/69 ,  A61P29/00

CPC classification number: A61K9/0053 ,  A61P1/00 ,  C08B37/003 ,  A61K31/409 ,  A61K47/6939 ,  A61P29/00

Abstract: The present disclosure relates to: a chitosan-bilirubin conjugate; particles; and an oral pharmaceutical composition including same. The conjugate and/or particles according to the present disclosure have excellent antioxidant and anti-inflammatory effects, exhibit systemic inflammation relieving effects as well as intestinal inflammatory reaction relieving effects, and have the effect of normalizing the balance of intestinal microflora distribution, and thus, can be useful for treating inflammatory bowel diseases, systemic and chronic inflammatory diseases, etc.

公开(公告)号：US20210395181A1

公开(公告)日：2021-12-23

申请号：US17417486

申请日：2021-04-06

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yong JON ,  Chan Ho CHUNG ,  Wonsik JUNG ,  Afia Tasnim RAHMAN

IPC: C07C59/52 ,  A61P29/00

Abstract: The present disclosure relates to a rosmarinic acid derivative, rosmarinic acid-derived particles, and a composition containing same for treating an inflammatory disease. The use of the rosmarinic acid derivative and rosmarinic acid-derived particles of the present disclosure enables the utilization of rosmarinic acid, which has been restricted in the utilization thereof due to low water solubility and low bioavailability, for a medicinal purpose.