公开(公告)号：US20240299539A1

公开(公告)日：2024-09-12

申请号：US18256798

申请日：2021-12-16

申请人： Iovance Biotherapeutics, Inc.

发明人： Maria FARDIS ,  Friedrich Graf Finck FINCKENSTEIN ,  Zelanna GOLDBERG

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C12N5/0783

CPC分类号： A61K39/4611 ,  A61K39/395 ,  A61K39/464499 ,  A61P35/00 ,  C12N5/0636 ,  A61K2039/507 ,  A61K2239/39 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2502/00

摘要： The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CT-LA-4 and PD-1 inhibitors and/or PD-L1 inhibitors as described herein.

公开(公告)号：US20240325446A1

公开(公告)日：2024-10-03

申请号：US18674562

申请日：2024-05-24

申请人： Iovance Biotherapeutics, Inc.

发明人： Maria FARDIS ,  Friedrich Graf Finck FINCKENSTEIN ,  Zelanna GOLDBERG

IPC分类号： A61K35/17 ,  A61K38/20 ,  A61K39/00 ,  A61P35/04 ,  C07K16/28

CPC分类号： A61K35/17 ,  A61K38/2013 ,  A61P35/04 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/545

摘要： The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CTLA-4 and PD-1 inhibitors and/or PD-L1 inhibitors as described herein.

公开(公告)号：US20240123067A1

公开(公告)日：2024-04-18

申请号：US18256853

申请日：2021-12-16

申请人： Iovance Biotherapeutics, Inc.

发明人： Friedrich Graf Finck FINCKENSTEIN ,  Maria FARDIS

IPC分类号： A61K39/00 ,  A61P35/00 ,  C12N5/0783

CPC分类号： A61K39/4611 ,  A61K39/464499 ,  A61P35/00 ,  C12N5/0636 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/515 ,  C12N2502/11

摘要： Provided herein are methods for generating TILs that can then be employed in the treatment of patients having a cancer (e.g., a pediatric cancer, a uveal melanoma or mesothelioma).