公开(公告)号：US20220002362A1

公开(公告)日：2022-01-06

申请号：US17293568

申请日：2019-11-13

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Wondo HEO ,  Sungsoo KIM ,  Sang Kyu LEE ,  Taeyoon KYUNG

IPC: C07K14/47 ,  C07K14/705 ,  C12N15/86

Abstract: Provided is a CRY2 variant in which E279 and/or E281 having a negative charge in a N277SEGE281 sequence of SEQ ID NO: 1 is substituted with any one selected from the neutral amino acid group of alanine (A), isoleucine (I), leucine (L), valine (V), phenylalanine (F), methionine (M) and tryptophan (W), or in which S278 or G280 of a N277SEGE281 sequence of SEQ ID NO: 1 is substituted with any one selected from the bulky amino acid group of tryptophan (W) and phenylalanine (F).