公开(公告)号：US20180243237A1

公开(公告)日：2018-08-30

申请号：US15964635

申请日：2018-04-27

申请人： Grünenthal Gmbh

发明人： Elisabeth Arkenau-Maric ,  Johannes Bartholomaus ,  Heinrich Kugelmann

IPC分类号： A61K31/135 ,  A61K45/06 ,  A61K9/20 ,  B29C47/40 ,  B29C47/06 ,  B29C47/00 ,  A61K47/10 ,  A61K36/81 ,  A61K36/67 ,  A61K31/5513 ,  A61K31/515 ,  A61K31/485 ,  A61K31/4725 ,  B29K71/00 ,  B29K105/00 ,  B29L31/00

CPC分类号： A61K31/135 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2077 ,  A61K9/2095 ,  A61K31/4725 ,  A61K31/485 ,  A61K31/515 ,  A61K31/5513 ,  A61K36/67 ,  A61K36/81 ,  A61K45/06 ,  A61K47/10 ,  B29C48/0011 ,  B29C48/0022 ,  B29C48/022 ,  B29C48/03 ,  B29C48/18 ,  B29C48/40 ,  B29K2071/02 ,  B29K2105/0035 ,  B29K2105/0088 ,  B29K2105/25 ,  B29K2995/007 ,  B29K2995/0089 ,  B29L2031/753 ,  A61K2300/00

摘要： The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.

公开(公告)号：US20130320592A1

公开(公告)日：2013-12-05

申请号：US13962098

申请日：2013-08-08

申请人： Grünenthal GmbH

发明人： Elisabeth Arkenau-Maric ,  Johannes Bartholomaus

IPC分类号： A61K9/20

CPC分类号： A61K9/2095 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2072 ,  A61K31/135 ,  A61K31/485 ,  A61K31/515 ,  A61K31/5513 ,  B30B11/16 ,  B30B11/34

摘要： The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.