公开(公告)号：US11674962B2

公开(公告)日：2023-06-13

申请号：US16041363

申请日：2018-07-20

申请人： Genentech, Inc. ,  Foundation Medicine, Inc.

发明人： Craig Anthony Cummings ,  Yan Li ,  Sarah Margaret Shagan ,  Erica Beth Schleifman ,  David Shames ,  David Fabrizio ,  Daniel Lieber ,  Geoffrey Alan Otto ,  Mark Kennedy ,  Travis Clark ,  Doron Lipson ,  Jie He ,  Shan Zhong

IPC分类号： C12Q1/68 ,  C12Q1/6883 ,  G01N33/574 ,  C07K16/28 ,  G16H50/50 ,  G16H50/30 ,  G16H50/70 ,  G16H50/20 ,  A61P35/00 ,  G06F16/28 ,  C07K14/735 ,  A61K39/00

CPC分类号： G01N33/574 ,  A61P35/00 ,  C07K14/70535 ,  C07K16/2827 ,  C07K16/2896 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N33/57492 ,  G06F16/285 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/24 ,  C12Q2600/156 ,  G01N2333/70532 ,  G01N2800/52

摘要： The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.