公开(公告)号：US20170349639A1

公开(公告)日：2017-12-07

申请号：US15385528

申请日：2016-12-20

Applicant: Genentech, Inc.

Inventor： James A. ERNST ,  Paul POLAKIS ,  Bonnee RUBINFELD ,  Venita I. DEALMEIDA

IPC: C07K14/47 ,  C07K14/71 ,  A61K38/00

CPC classification number: C07K14/4702 ,  A61K38/00 ,  C07K14/71 ,  G01N2333/71 ,  Y02A50/473

Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.