公开(公告)号：US20250011450A1

公开(公告)日：2025-01-09

申请号：US18749445

申请日：2024-06-20

Applicant: Genentech, Inc.

Inventor： Gregory Alan LAZAR ,  Brandon LEONARD ,  Matthew G. ROMEI

IPC: C07K16/28 ,  C12N15/10

Abstract: Provided herein are antibodies such as human or humanized antibodies with a modified heavy chain variable (VH) domain such that the antibodies adopt a constrained conformation (e.g., an i-shaped format) upon engaging the antigen(s) the antibodies bind to, thereby confer agonistic activities. In some cases, the antibodies are full-length antibodies (e.g., IgG antibodies). In some cases, the antibodies are monovalent antibodies (e.g., Fabs). In some cases, the antibodies target receptors which require clustering for activation (e.g., TNFR superfamily receptors). In some cases, the antibodies target two antigens on a molecule that have two or more subunits (e.g., an IL-2 receptor). Also provided herein are methods of making and using such antibodies and libraries for discovering or screening such antibodies.

公开(公告)号：US20230279067A1

公开(公告)日：2023-09-07

申请号：US18057604

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  lraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/39541 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220289803A1

公开(公告)日：2022-09-15

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  Iraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28

Abstract: The invention provides an effectoriess immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.