公开(公告)号：US20140193414A1

公开(公告)日：2014-07-10

申请号：US14100211

申请日：2013-12-09

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Lauric Haber ,  Gabriele Schaefer ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  C07K16/28 ,  A61K47/48

CPC classification number: C07K16/28 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

公开(公告)号：US20140056899A1

公开(公告)日：2014-02-27

申请号：US14066258

申请日：2013-10-29

Applicant: GENENTECH, INC.

Inventor： Germaine Fuh ,  Lauric Haber ,  Gabriele Schaefer ,  Mark X. Sliwkowski

IPC: C07K16/28

CPC classification number: A61K47/48569 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

Abstract translation: 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。

公开(公告)号：US09327035B2

公开(公告)日：2016-05-03

申请号：US14066258

申请日：2013-10-29

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Lauric Haber ,  Gabriele Schaefer ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/48 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K47/48569 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

Abstract translation: 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。