公开(公告)号：US09541561B2

公开(公告)日：2017-01-10

申请号：US13843574

申请日：2013-03-15

Applicant: Electronics and Telecommunications Research Institute

Inventor： Chang-Beom Kim ,  Kibong Song ,  Kwan Su Kim

IPC: G01N33/543 ,  G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/54326 ,  G01N33/54373

Abstract: Provided is a method for diagnosing Alzheimer/s disease using a decomposed biomaterial. The method includes: preparing magnetic particles on which primary capture antibodies specifically bound to beta-amyloid are adsorbed; decomposing a biomaterial including beta-amyloid; binding the beta-amyloid to the primary capture antibodies; binding secondary capture antibodies labeled with a fluorescent material to the magnetic particles bound to the beta-amyloid to form a complex; disposing the complex in a channel region of a photo field effect transistor in which a photocurrent is changed according to the amount of incident light; and measuring the photocurrent changed by light excited from the complex to quantify the concentration of the beta-amyloid existing in the biomaterial.

Abstract translation: 提供了使用分解生物材料诊断阿尔茨海默病的方法。 该方法包括：制备其上吸附了特异性结合β-淀粉样蛋白的初级捕获抗体的磁性颗粒; 分解包括β-淀粉样蛋白在内的生物材料; 将β-淀粉样蛋白与初级捕获抗体结合; 用荧光材料标记的结合二次捕获抗体结合到β-淀粉样蛋白上形成复合物的磁性颗粒; 将复合物设置在光电流根据入射光量变化的光电场效应晶体管的沟道区域中; 并测量由络合物激发的光改变的光电流，以量化存在于生物材料中的β-淀粉样蛋白的浓度。