公开(公告)号：US20170165236A1

公开(公告)日：2017-06-15

申请号：US15033311

申请日：2014-10-31

申请人： Celgene International II Sàrl

发明人： Esther MARTINBOROUGH ,  Marcus F. BOEHM ,  Adam Richard YEAGER ,  Junko TAMIYA, ,  Liming HUANG ,  Enugurthi BRAHMACHARY ,  Manisha MOORJANI ,  Gregg Alan TIMONY ,  Jennifer L. BROOKS ,  Robert PEACH ,  Fiona Lorraine SCOTT ,  Michael Allen HANSON

IPC分类号： A61K31/4245 ,  A61K31/225 ,  A61K31/137 ,  A61K38/03 ,  A61K39/395 ,  A61K31/427 ,  A61K38/21 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/635 ,  A61K31/4704 ,  C07K16/28

CPC分类号： A61K31/4245 ,  A61K31/137 ,  A61K31/225 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/635 ,  A61K38/03 ,  A61K38/215 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2839 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2893 ,  C07K2317/24 ,  A61K2300/00

摘要： Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided, including compounds which modulate subtype 1 of the S1P receptor, and methods of their therapeutic and/or prophylactic use in combination with at least one other medicament adapted for treatment of a malcondition for which activation of S1P1 is medically indicated, such as multiple sclerosis.