公开(公告)号：US20220348928A1

公开(公告)日：2022-11-03

申请号：US17626768

申请日：2020-07-16

Applicant: CUROCELL INC. ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gun Soo KIM ,  Mi Kyung KIM ,  Chan Hyuk KIM ,  Young-Ho LEE ,  HyeongJi LEE

IPC: C12N15/113 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K35/17 ,  A61P35/00

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of two genes that weaken the function of the immune cell.