公开(公告)号：US20240288367A1

公开(公告)日：2024-08-29

申请号：US18574571

申请日：2022-07-01

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Lev T. Perelman

IPC: G01N21/51 ,  C12Q1/04 ,  G01N21/47 ,  G01N33/49

CPC classification number: G01N21/51 ,  C12Q1/04 ,  G01N33/49 ,  G01N2021/4704 ,  G01N2201/0683

Abstract: Methods for identifying bacterial species in biofluid samples (e.g., whole blood samples) are described. The methods rely on optical spectroscopy, and enable rapid detection and identification of bacteria directly from whole blood. Not only can LSS-based techniques detect and identify bacteria in biofluids such as whole blood, but that species-level identification can potentially be made based on a small number of bacterial cells, without the need for observing entire colonies or performing susceptibility testing. The methods may comprise illuminating the biofluid sample with input light, detecting scattered light produced by the biofluid sample in response to the illuminating, generating first data indicative of a measured scattering spectrum associated with the biofluid sample using the detected scattered light, and identifying whether at least one of the bacterial species is present in the biofluid sample using the first data.

公开(公告)号：US20200297266A1

公开(公告)日：2020-09-24

申请号：US16487768

申请日：2018-02-23

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Lev T. Perelman

IPC: A61B5/00 ,  A61B8/08 ,  A61B10/00

Abstract: Described herein are embodiments of an approach to diagnosing pancreatic cystic lesions using light scattering spectroscopy. In some embodiments, the approach includes an apparatus including a spatial gating probe to isolate light reflected by the epithelial tissue of the internal cyst surface using spatial gating. In some further embodiments, the apparatus includes a scanning fiber probe that is capable of rotational and linear motion in order to scan the entire internal surface of the cyst. Use of such an approach may be advantageous to improve the accuracy of diagnosing pancreatic cystic lesions as cancerous, precancerous, or benign.

公开(公告)号：US11931163B2

公开(公告)日：2024-03-19

申请号：US16487768

申请日：2018-02-23

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Lev T. Perelman

IPC: A61B5/00 ,  A61B8/08 ,  A61B10/00

CPC classification number: A61B5/425 ,  A61B5/0075 ,  A61B5/0084 ,  A61B8/0841 ,  A61B10/0045 ,  A61B2010/0061 ,  A61B2562/0242

Abstract: Described herein are embodiments of an approach to diagnosing pancreatic cystic lesions using light scattering spectroscopy. In some embodiments, the approach includes an apparatus including a spatial gating probe to isolate light reflected by the epithelial tissue of the internal cyst surface using spatial gating. In some further embodiments, the apparatus includes a scanning fiber probe that is capable of rotational and linear motion in order to scan the entire internal surface of the cyst. Use of such an approach may be advantageous to improve the accuracy of diagnosing pancreatic cystic lesions as cancerous, precancerous, or benign.