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公开(公告)号：US08987251B2
公开(公告)日：2015-03-24
申请号：US14057882
申请日：2013-10-18
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Hicks , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC: A61K31/437 , C07D471/04 , C07D451/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/437 , C07D451/06 , C07D519/00
Abstract: Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification.
Abstract translation: 本文提供了一种在哺乳动物中治疗PIM-1和/或PIM-3和/或PIM-3激酶介导的病症的方法，其包括向所述哺乳动物施用治疗有效量的式I化合物：其中 A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有说明书中给出的含义。
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公开(公告)号：US20140045835A1
公开(公告)日：2014-02-13
申请号：US14054459
申请日：2013-10-15
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Robert Kirk DeLisle , Julie Marie Hicks , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein are methods of treating diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases by administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula I: in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification.
Abstract translation: 本文提供了通过向有需要的哺乳动物施用治疗有效量的式I化合物来治疗由PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病的方法：其中B，R1， R1a，R2，R3，R4，R5，R6，R7，R10和R11具有说明书中给出的含义。
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公开(公告)号：US20140045817A1
公开(公告)日：2014-02-13
申请号：US14057882
申请日：2013-10-18
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Laura L. Celeste , T. Gregg Davis , Robert Kirk DeLisle , Julie Marie Hicks , Stefan D. Gross , Erik James Hicken , Leila J. Jackson , Nicholas C. Kallan , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , Jed Pheneger , Bryson Rast , John E. Robinson , Stephen T. Schlachter , George T. Topalov , A. Dale Wright , Qian Zhao
IPC: C07D471/04 , C07D451/06
CPC classification number: C07D471/04 , A61K31/437 , C07D451/06 , C07D519/00
Abstract: Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification.
Abstract translation: 本文提供了一种在哺乳动物中治疗PIM-1和/或PIM-3和/或PIM-3激酶介导的病症的方法，其包括向所述哺乳动物施用治疗有效量的式I化合物：其中 A，B，R1，R1a，R2，R3，R4，R5，R6和R7具有说明书中给出的含义。
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![Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors](/abs-image/US/2017/11/07/US09809590B2/abs.jpg.150x150.jpg)
公开(公告)号：US09809590B2
公开(公告)日：2017-11-07
申请号：US14858029
申请日：2015-09-18
Applicant: Array BioPharma Inc.
Inventor： Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC: C07D471/04 , A61K45/06 , A61K31/496
CPC classification number: C07D471/04 , A61K31/496 , A61K45/06
Abstract: Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
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Patent Agency Ranking
公开(公告)号：US12171739B2
公开(公告)日：2024-12-24
申请号：US17940902
申请日：2022-09-08
Applicant: Array BioPharma Inc.
Inventor： Joseph P. Lyssikatos , Julie Marie Hicks , Fredrik P. Marmsater , Qian Zhao
IPC: C07D403/12 , A61K31/337 , A61K31/513 , A61K31/517 , A61K39/395 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00
Abstract: This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
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公开(公告)号：US10780073B2
公开(公告)日：2020-09-22
申请号：US15975323
申请日：2018-05-09
Applicant: ARRAY BIOPHARMA, INC.
Inventor： Joseph P. Lyssikatos , Julie Marie Hicks , Fredrik P. Marmsater , Qian Zhao
IPC: A61K31/337 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D519/00 , C07D471/04 , A61K31/513 , A61K31/517 , A61K39/395
Abstract: This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
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公开(公告)号：US09693989B2
公开(公告)日：2017-07-04
申请号：US14034361
申请日：2013-09-23
Applicant: ARRAY BIOPHARMA, INC.
Inventor： Joseph P. Lyssikatos , Julie Marie Hicks , Fredrik P. Marmsater , Qian Zhao
IPC: A61K31/337 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00 , A61K31/513 , A61K31/517 , A61K39/395
CPC classification number: A61K31/337 , A61K31/513 , A61K31/517 , A61K39/3955 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00
Abstract: This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
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![SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS](/abs-image/US/2016/01/07/US20160002232A1/abs.jpg.150x150.jpg)
8.发明申请SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS 有权取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-羧酰胺化合物作为III型受体酪氨酸激酶抑制剂公开(公告)号：US20160002232A1
公开(公告)日：2016-01-07
申请号：US14858029
申请日：2015-09-18
Applicant: ARRAY BIOPHARMA INC.
Inventor： Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC: C07D471/04 , A61K45/06 , A61K31/496
CPC classification number: C07D471/04 , A61K31/496 , A61K45/06
Abstract: Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
Abstract translation: 用于治疗哺乳动物纤维化，骨相关疾病，癌症，自身免疫疾病，炎性疾病，心血管疾病，疼痛和灼伤的化合物。
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公开(公告)号：US08895550B2
公开(公告)日：2014-11-25
申请号：US14054459
申请日：2013-10-15
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Robert Kirk DeLisle , Julie Marie Hicks , Erik James Hicken , Joseph P. Lyssikatos , Fredrik P. Marmsater , Mark C. Munson , John E. Robinson , Qian Zhao
IPC: A61K31/437 , A61K31/4353 , C07D471/04
CPC classification number: C07D471/04
Abstract: Provided herein are methods of treating diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases by administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula I: in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification.
Abstract translation: 本文提供了通过向有需要的哺乳动物施用治疗有效量的式I化合物来治疗由PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病的方法：其中B，R1， R1a，R2，R3，R4，R5，R6，R7，R10和R11具有说明书中给出的含义。
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