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公开(公告)号：US10233237B2
公开(公告)日：2019-03-19
申请号：US14086190
申请日：2013-11-21
Applicant: AMGEN INC.
Inventor： Gunasekaran Kannan , Monica Florio , Zhi Liu , Wei Yan
Abstract: The present application is directed to heterodimeric antibodies and methods of use.
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公开(公告)号：US20230212318A1
公开(公告)日：2023-07-06
申请号：US17727316
申请日：2022-04-22
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Mark L. Michaels , Patrick Baeuerle
IPC: C07K16/46 , C07K14/725 , C07K16/28 , C07K16/32
CPC classification number: C07K16/468 , C07K14/7051 , C07K16/32 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/50
Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.
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公开(公告)号：US20230212297A1
公开(公告)日：2023-07-06
申请号：US17697632
申请日：2022-03-17
Applicant: Amgen Inc.
Inventor： Luis G. Borges , Patrick Baeuerle , Wei Yan , Mark L. Michaels
CPC classification number: C07K16/2863 , C07K16/00 , C07K16/28 , C07K16/32 , C07K16/40 , C07K16/468 , C07K16/2803 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/60 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/565 , C07K2317/622 , C07K2319/00
Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.
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公开(公告)号：US11198732B2
公开(公告)日：2021-12-14
申请号：US16413810
申请日：2019-05-16
Applicant: AMGEN INC.
Inventor： Zhi Liu , Gunasekaran Kannan , Wei Yan
Abstract: Disclosed are Fc-containing proteins comprising a binding region and a variant Fc region that can elicit one or more immune effector function and/or bind to an Fc receptor more effectively than a similar Fc-containing protein comprising a wild type Fc region. Also disclosed are nucleic acids encoding such Fc-containing proteins, methods for making such proteins, and methods of treatment utilizing such proteins.
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公开(公告)号：US20190153086A1
公开(公告)日：2019-05-23
申请号：US16267758
申请日：2019-02-05
Applicant: Amgen Inc.
Inventor： Gunasekaran Kannan , Monica Florio , Zhi Liu , Wei Yan
Abstract: The present application is directed to heterodimeric antibodies and methods of use.
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Patent Agency Ranking
公开(公告)号：US20190002568A1
公开(公告)日：2019-01-03
申请号：US16032342
申请日：2018-07-11
Applicant: AMGEN INC.
Inventor： Luis G. Borges , Patrick Bauerle , Wei Yan , Mark L. Michaels
Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.
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公开(公告)号：US20170247476A1
公开(公告)日：2017-08-31
申请号：US15513011
申请日：2015-09-24
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Mark L. Michaels , Patrick Baeuerle
IPC: C07K16/46 , C07K16/28 , C07K16/32 , C07K14/725
CPC classification number: C07K16/468 , C07K14/7051 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/50
Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.
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公开(公告)号：US20140154254A1
公开(公告)日：2014-06-05
申请号：US14086190
申请日：2013-11-21
Applicant: AMGEN INC.
Inventor： Gunasekaran Kannan , Monica Florio , Zhi Liu , Wei Yan
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: The present application is directed to heterodimeric antibodies and methods of use.
Abstract translation: 本申请涉及异二聚体抗体和使用方法。
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公开(公告)号：US11634502B2
公开(公告)日：2023-04-25
申请号：US14774320
申请日：2014-03-13
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20230055407A1
公开(公告)日：2023-02-23
申请号：US17702131
申请日：2022-03-23
Applicant: AMGEN INC.
Inventor： Mark L. Michaels , Luis G. Borges , Wei Yan
Abstract: Described herein is a dimeric, bispecific antibody format. Each polypeptide chain of the dimer comprises an immunoglobulin variable region, an immunoglobulin constant region, an Fc polypeptide chain, another immunoglobulin variable region, and another immunoglobulin constant region. Also described are methods of making and using such antibodies.
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