公开(公告)号：US11753475B2

公开(公告)日：2023-09-12

申请号：US15885998

申请日：2018-02-01

Applicant: AMGEN INC.

Inventor： Luis G. Borges ,  Patrick A. Baeuerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/00 ,  C07K16/32 ,  C07K16/46 ,  C07K16/40 ,  A61K39/00

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/32 ,  C07K16/40 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

公开(公告)号：US20180230220A1

公开(公告)日：2018-08-16

申请号：US15885998

申请日：2018-02-01

Applicant: AMGEN INC.

Inventor： Luis G. Borges ,  Patrick A. Baeuerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C07K16/00 ,  C07K16/46 ,  A61K39/00

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.