公开(公告)号：US20180087079A1

公开(公告)日：2018-03-29

申请号：US15828215

申请日：2017-11-30

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C12P21/00 ,  C07D471/04 ,  C07K16/00

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

公开(公告)号：US20150353542A1

公开(公告)日：2015-12-10

申请号：US14760978

申请日：2013-12-11

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C07D471/04

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

Abstract translation: 提供调节表达目的蛋白质的细胞培养物性质的方法。 在各种实施方案中，所述方法涉及将细胞周期抑制剂加入到生长细胞培养物中。

公开(公告)号：US20150376221A1

公开(公告)日：2015-12-31

申请号：US14767737

申请日：2014-02-20

Applicant: AMGEN INC.

Inventor： John Gordon Allen ,  Christopher H. FOTSCH ,  Michael J. FROHN ,  John Douglas MCCARTER ,  Mirna MUJACIC ,  Alexander J. PICKRELL

IPC: C07H7/02 ,  C12N5/073 ,  C07K16/28

CPC classification number: C07H7/02 ,  C07D309/10 ,  C07D309/14 ,  C07K16/2875 ,  C07K2317/14 ,  C07K2317/41 ,  C12N5/0603 ,  C12N2501/999 ,  C12N2510/00

Abstract: Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other variables are provided herein.

Abstract translation: 式（I）的化合物可用作糖基化的调节剂。 式（I）的化合物具有以下结构：（I），本文提供其它变量的定义。