公开(公告)号：US20190290648A1

公开(公告)日：2019-09-26

申请号：US16347942

申请日：2017-11-03

Applicant: AMGEN INC.

Inventor： Yinhong CHEN ,  Paul John DRANSFIELD ,  James S. HARVEY ,  Julie Anne HEATH ,  Jonathan HOUZE ,  Aarif Yusuf KHAKOO ,  David J. KOPECKY ,  Su-Jen LAI ,  Zhihua MA ,  Nobuko NISHIMURA ,  Vatee PATTAROPONG ,  Gayathri SWAMINATH ,  Wen-Chen YEH ,  Philip Dean RAMSDEN

IPC: A61K31/506 ,  A61P9/04 ,  C07D403/12 ,  C07D405/14 ,  C07D401/14

Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.