公开(公告)号：US20120277433A1

公开(公告)日：2012-11-01

申请号：US13519600

申请日：2010-12-28

申请人： Mahendranath Rao Narasimha Rao ,  Attimogae Shivamurthy Harisha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Mahendranath Rao Narasimha Rao ,  Attimogae Shivamurthy Harisha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07D471/04

CPC分类号： C07D471/08

摘要： The present invention is directed to an improved process for the preparation of substituted quinoxalines by cyclization of the corresponding dianiline in the presence of ion exchange resin.

摘要翻译： 本发明涉及通过在离子交换树脂的存在下环化相应的二苯胺来制备取代的喹喔啉的改进方法。

公开(公告)号：US09169232B2

公开(公告)日：2015-10-27

申请号：US14344644

申请日：2012-09-14

申请人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07D317/36 ,  C07D317/40

CPC分类号： C07D317/36 ,  C07D317/40

摘要： The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

摘要翻译： 本发明涉及式（I）的阿托伐醌前药化合物。 因此，本发明提供了一种方法，该方法包括将Atovaquone（II）与5-甲基-4-氯甲基二环（III）在合适的溶剂体系中缩合，任选地随后进行蒸馏和结晶，以高产率提供式（I）的阿托伐醌前药化合物 ，纯度高，适合大规模生产。

公开(公告)号：US20110004024A1

公开(公告)日：2011-01-06

申请号：US12921096

申请日：2009-03-06

申请人： Sanjay Sukumar Saralya ,  Shashikumar Hiriyalu Somashekar ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Koottungalmadhom Ramaswamy Ranganathan ,  Veerasamy Ananthalakshmi ,  Govindarajalu Jeyaraman ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralya ,  Shashikumar Hiriyalu Somashekar ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Koottungalmadhom Ramaswamy Ranganathan ,  Veerasamy Ananthalakshmi ,  Govindarajalu Jeyaraman ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07C45/48 ,  C07C49/747

CPC分类号： C07C46/00 ,  C07C46/10 ,  C07C50/32 ,  C07C2601/14 ,  C07C2602/10 ,  C07C50/24

摘要： The present invention relates the use of 2,3-dihalonaphthoquinone compounds of Formula I wherein R1 and R2 are leaving groups like halogens selected from the group comprising Cl, Br, I and F and the R1 and R2 may be the same halogen or may contain different halogen groups, or sulphonyl groups, for making napthoquinone compounds of Formula IA wherein X is any aryl, heteroaryl, alkyl, cyclohexyl, substituted cylohexyl groups and the like.

摘要翻译： 本发明涉及式I的2,3-二卤萘醌化合物，其中R 1和R 2离去基团如选自Cl，Br，I和F的卤素，R 1和R 2可以是相同的卤素或可以含有 不同的卤素基团或磺酰基基团，用于制备式IA的萘醌化合物，其中X是任何芳基，杂芳基，烷基，环己基，取代的环己基等。

公开(公告)号：US20140343297A1

公开(公告)日：2014-11-20

申请号：US14344644

申请日：2012-09-14

申请人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  (none) Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  (none) Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07D317/36

CPC分类号： C07D317/36 ,  C07D317/40

摘要： The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

摘要翻译： 本发明涉及式（I）的阿托伐醌前药化合物。 因此，本发明提供了一种方法，该方法包括将Atovaquone（II）与5-甲基-4-氯甲基二环（III）在合适的溶剂体系中缩合，任选地随后进行蒸馏和结晶，以高产率提供式（I）的阿托伐醌前药化合物 ，纯度高，适合大规模生产。

公开(公告)号：US08283499B2

公开(公告)日：2012-10-09

申请号：US12921096

申请日：2009-03-06

申请人： Sanjay Sukumar Saralya ,  Shashikumar Hiriyalu Somashekar ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Koottungalmadhom Ramaswamy Ranganathan ,  Veerasamy Ananthalakshmi ,  Govindarajalu Jeyaraman ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralya ,  Shashikumar Hiriyalu Somashekar ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Koottungalmadhom Ramaswamy Ranganathan ,  Veerasamy Ananthalakshmi ,  Govindarajalu Jeyaraman ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07C45/48 ,  C07C49/747

CPC分类号： C07C46/00 ,  C07C46/10 ,  C07C50/32 ,  C07C2601/14 ,  C07C2602/10 ,  C07C50/24

摘要： The present invention relates the use of 2,3-dihalonaphthoquinone compounds of Formula I wherein R1 and R2 are leaving groups like halogens selected from the group comprising Cl, Br, I and F and the R1 and R2 may be the same halogen or may contain different halogen groups, or sulphonyl groups, for making napthoquinone compounds of Formula IA wherein X is any aryl, heteroaryl, alkyl, cyclohexyl, substituted cylohexyl groups and the like.

摘要翻译： 本发明涉及式I的2,3-二卤萘醌化合物，其中R 1和R 2离去基团如选自Cl，Br，I和F的卤素，R 1和R 2可以是相同的卤素或可以含有 不同的卤素基团或磺酰基基团，用于制备式IA的萘醌化合物，其中X是任何芳基，杂芳基，烷基，环己基，取代的环己基等。