公开(公告)号：US20250127475A1

公开(公告)日：2025-04-24

申请号：US18937767

申请日：2024-11-05

Applicant: LightLab Imaging, Inc.

Inventor： Lorina Dascal ,  Itai Winkler

IPC: A61B6/00 ,  A61B5/00 ,  A61B6/50 ,  A61B8/12 ,  G06T5/50 ,  G06T7/00 ,  G06T7/33 ,  G06T7/73

Abstract: The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).

公开(公告)号：US20250082206A1

公开(公告)日：2025-03-13

申请号：US18960195

申请日：2024-11-26

Applicant: LightLab Imaging, Inc.

Inventor： Christopher Petroff ,  Joseph M. Schmitt

IPC: A61B5/00 ,  A61B1/015 ,  A61B1/07 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/107

Abstract: In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.

公开(公告)号：US12193789B2

公开(公告)日：2025-01-14

申请号：US16937117

申请日：2020-07-23

Applicant: LightLab Imaging, Inc.

Inventor： Christopher Petroff ,  Joseph M. Schmitt

IPC: A61B5/00 ,  A61B1/015 ,  A61B1/07 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/107

Abstract: In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement.

公开(公告)号：US11923067B2

公开(公告)日：2024-03-05

申请号：US14115527

申请日：2013-03-12

Applicant: Lightlab Imaging, Inc.

Inventor： Joseph M. Schmitt ,  Hiram Bezerra ,  Christopher Petroff ,  Ajay Gopinath

IPC: G16H30/20 ,  A61B5/00 ,  A61B5/02 ,  A61B5/107 ,  A61B90/00 ,  A61F2/82 ,  A61F2/86 ,  G16H20/40

CPC classification number: G16H30/20 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/1076 ,  A61F2/86 ,  G16H20/40 ,  A61B2090/061 ,  A61F2/82 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/006

Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.

公开(公告)号：US20230389799A1

公开(公告)日：2023-12-07

申请号：US18237614

申请日：2023-08-24

Applicant: LightLab Imaging, Inc.

Inventor： Ajay Gopinath ,  Mark Hoeveler

IPC: A61B5/00 ,  A61B34/10 ,  A61B34/00 ,  G06T7/62 ,  G06T7/13 ,  G16H30/20 ,  G16H30/40 ,  G16H40/40 ,  G16H40/63 ,  G06F3/0484 ,  G06T7/00 ,  G06V10/764 ,  G06V10/82

CPC classification number: A61B5/0066 ,  A61B34/10 ,  A61B34/25 ,  G06T7/62 ,  G06T7/13 ,  G16H30/20 ,  G16H30/40 ,  G16H40/40 ,  G16H40/63 ,  G06F3/0484 ,  G06T7/0012 ,  G06V10/764 ,  G06V10/82 ,  A61B2034/107 ,  A61B2034/108 ,  A61F2/958

Abstract: In part, the disclosure relates to method of displaying a representation of an artery. The method may include storing an intravascular image dataset in a memory device of a diagnostic imaging system, the intravascular image dataset generated in response to intravascular imaging of a segment of an artery; automatically detecting lumen boundary of the segment on a per frame basis; automatically detecting EEL and displaying a stent sizing workflow. In part, the disclosure also relates to automatically detecting one or more regions of calcium relative to lumen boundary of the segment; calculating an angular or circumferential measurement of detected calcium for one or more frames; calculating a calcium thickness of detected calcium for one or more frames; and displaying the calcium thickness and the angular or circumferential measurement of detected calcium for a first frame of the one or more frames.

公开(公告)号：US20230230262A1

公开(公告)日：2023-07-20

申请号：US18125213

申请日：2023-03-23

Applicant: LightLab Imaging, Inc.

Inventor： Lorina Dascal ,  Itai Winkler

IPC: G06T7/33 ,  G06T7/73 ,  G06T7/00 ,  A61B6/00

CPC classification number: G06T7/33 ,  G06T7/73 ,  G06T7/0014 ,  A61B6/504 ,  A61B6/5247 ,  G06T2207/30104 ,  G06T2207/30204 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/10116 ,  G06T2207/10016 ,  G06T2207/30021

Abstract: The disclosure relates generally to the field of vascular system and peripheral vascular system data collection, imaging, image processing and feature detection relating thereto. In part, the disclosure more specifically relates to methods for detecting position and size of contrast cloud in an x-ray image including with respect to a sequence of x-ray images during intravascular imaging. Methods of detecting and extracting metallic wires from x-ray images are also described herein such as guidewires used in coronary procedures. Further, methods for of registering vascular trees for one or more images, such as in sequences of x-ray images, are disclosed. In part, the disclosure relates to processing, tracking and registering angiography images and elements in such images. The registration can be performed relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT) or intravascular ultrasound (IVUS).

公开(公告)号：US20230125217A1

公开(公告)日：2023-04-27

申请号：US17972969

申请日：2022-10-25

Applicant: LightLab Imaging, Inc.

Inventor： Eyal Gabay ,  Vitaly Gavensky ,  Jacob Segev ,  Yaroslav Shevchinsky ,  Dov Chanoch Waisman ,  Yuval Vaknin

IPC: A61B6/00

Abstract: Aspects of the disclosure provide for an x-ray detection device for detecting radiation scattered off of a target during an imaging procedure and generating temporal data indicating the time of occurrence of a pulse of radiation emitted towards the target. The temporal data can be sent to a host device and used to timestamp images generated from the pulses of radiation. The x-ray detection device is portable and can be installed in a catheterization laboratory or imaging environment to detect the occurrence of radiation, without occluding or partially occluding the beam source. Aspects of the disclosure also provide for a system for receiving temporal data generated by the x-ray detection device, and accurately tagging received image frames based on the temporal data.

公开(公告)号：US20220335616A1

公开(公告)日：2022-10-20

申请号：US17858468

申请日：2022-07-06

Applicant: LightLab Imaging, Inc.

Inventor： Gregory Patrick Amis ,  Ajay Gopinath ,  Mark Hoeveler

IPC: G06T7/00 ,  G06T7/38 ,  G16H50/50 ,  G16H50/30 ,  G16H30/40 ,  A61B5/02 ,  A61B5/00 ,  G06T11/00

Abstract: The present disclosure provides systems and methods to receiving OCT or IVUS image data frames to output one or more representations of a blood vessel segment. The image data frames may be stretched and/or aligned using various windows or bins or alignment features. Arterial features, such as the calcium burden, may be detected in each of the image data frames. The arterial features may be scored. The score may be a stent under-expansion risk. The representation may include an indication of the arterial features and their respective score. The indication may be a color coded indication.

公开(公告)号：US11367186B2

公开(公告)日：2022-06-21

申请号：US16928602

申请日：2020-07-14

Applicant: LightLab Imaging, Inc.

Inventor： Sonal Ambwani ,  Christopher E. Griffin

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/06 ,  G06T7/70 ,  G06V10/50

Abstract: The disclosure relates to stent detection and shadow detection in the context of intravascular data sets obtained using a probe such as, for example, and optical coherence tomography probe or an intravascular ultrasound probe.

公开(公告)号：US20220095934A1

公开(公告)日：2022-03-31

申请号：US17508272

申请日：2021-10-22

Applicant: LightLab Imaging, Inc.

Inventor： Joseph M. Schmitt ,  Joel M. Friedman ,  Christopher Petroff ,  Amr Elbasiony

IPC: A61B5/02 ,  A61B5/00

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.