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1.发明申请公开(公告)号：US20090143766A1
公开(公告)日：2009-06-04
申请号：US12320613
申请日：2009-01-29
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukumachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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2.发明授权公开(公告)号：US08207262B2
公开(公告)日：2012-06-26
申请号：US12283661
申请日：2008-09-15
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成大分子网络。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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公开(公告)号：US20090142309A1
公开(公告)日：2009-06-04
申请号：US12320609
申请日：2009-01-29
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08J3/246 , C08B37/0072 , C08G73/02 , C08H1/00 , C08J3/24 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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公开(公告)号：US20090042294A1
公开(公告)日：2009-02-12
申请号：US12283661
申请日：2008-09-15
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
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5.发明授权公开(公告)号：US07465766B2
公开(公告)日：2008-12-16
申请号：US11176544
申请日：2005-07-07
申请人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
发明人： Anthony Calabro , Lee Akst , Daniel Alam , James Chan , Aniq B. Darr , Kiyotaka Fukamachi , Richard A. Gross , David Haynes , Keiji Kamohara , Daniel P. Knott , Hilel Lewis , Alex Melamud , Anthony Miniaci , Marshall Strome
CPC分类号： C08B37/0072 , A61K47/6903 , C08G73/02 , C08H1/00 , C08J3/24 , C08J3/246 , C12N5/0068 , C12N5/0655 , C12N2533/30
摘要： A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
摘要翻译： 提供了可用于人造组织和组织工程应用的二羟基苯基交联的大分子网络，特别是提供用于各种组织类型的合成的，可植入的组织基质材料。 特别地，描述人造或合成软骨，声带材料，玻璃体材料，软组织材料和二尖瓣材料。 在一个实施方案中，网络由酪胺取代和交联的透明质酸分子组成，其中通过可以在体内进行的过氧化物酶介导的二联胺连接来实现交联。 二联苯键提供具有所需物理性质的稳定的，一致的透明质酸基水凝胶。
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