公开(公告)号：US06428955B1

公开(公告)日：2002-08-06

申请号：US08744481

申请日：1996-11-06

Applicant: Hubert Köster ,  Kai Tang ,  Dong-Jing Fu ,  Carsten W. Siegert ,  Daniel P. Little ,  Andreas Braun ,  Brigitte Darnhofer-Demar ,  Christian Jurinke ,  Dirk Van den Boom

Inventor： Hubert Köster ,  Kai Tang ,  Dong-Jing Fu ,  Carsten W. Siegert ,  Daniel P. Little ,  Andreas Braun ,  Brigitte Darnhofer-Demar ,  Christian Jurinke ,  Dirk Van den Boom

IPC: C12Q168

CPC classification number: C12Q1/6827 ,  G01N35/1067 ,  C12Q2537/113 ,  C12Q2535/113 ,  C12Q2521/325 ,  C12Q2565/627 ,  C12Q2535/131

Abstract: The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

Abstract translation: 本发明提供用于检测生物样品中特定核酸序列的基于快速和高精度的基于质谱仪的方法。 根据待检测的序列，可以使用例如诊断遗传病或染色体异常的方法; 疾病或病症的倾向，病原体感染或确定身份或遗传。