- 专利标题: Lentiviral vectors for generating immune responses against human T Lymphotrophic Virus Type 1
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申请号: US15112854申请日: 2015-01-27
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公开(公告)号: US09987351B2公开(公告)日: 2018-06-05
- 发明人: Deborah Revaud , Cecile Bauche
- 申请人: THERAVECTYS
- 申请人地址: FR Paris
- 专利权人: THERAVECTYS
- 当前专利权人: THERAVECTYS
- 当前专利权人地址: FR Paris
- 代理机构: Whitham, Curtis & Cook, P.C.
- 优先权: EP14290009 20140127
- 国际申请: PCT/IB2015/050598 WO 20150127
- 国际公布: WO2015/111024 WO 20150730
- 主分类号: A61K39/21
- IPC分类号: A61K39/21 ; A61K39/12 ; C07K14/05 ; C07K14/15 ; C07K14/005 ; C12N7/00 ; C12N15/86 ; A61K39/00
摘要:
The present invention relates to compositions, methods, and uses employing lentiviral vector particles for induction of an immune response by administration to a human, wherein the lentiviral vector particles comprise a lentiviral vector, wherein the DNA of the lentiviral vector comprises a promoter directing expression of a HTLV-1 p12p30-Tax-HBZ fusion protein. The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.
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