- 专利标题： Inhibitors targeting drug-resistant influenza A
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申请号： US14363116申请日： 2012-12-06
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公开(公告)号： US09884832B2公开(公告)日： 2018-02-06
- 发明人: William F. DeGrado , Jizhou Wang , Jun Wang , Hyunil Jo , Belgin Canturk
- 申请人： The Trustees of The University of Pennsylvania
- 申请人地址： US PA Philadelphia
- 专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Baker & Hostetler LLP
- 国际申请： PCT/US2012/068163 WO 20121206
- 国际公布： WO2013/086131 WO 20130613
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; A61K31/422 ; C07D271/06 ; C07D207/335 ; A61K31/417 ; A61K45/06 ; C07C215/50 ; A61K31/137 ; A61K31/155 ; A61K31/15 ; C07C211/38 ; C07C271/28 ; A61K31/27 ; C07C255/58 ; A61K31/26 ; C07D257/04 ; A61K31/41 ; A61K31/4245 ; C07D213/38 ; A61K31/4402 ; C07D233/88 ; A61K31/505 ; C07D261/08 ; A61K31/5377 ; C07C211/27 ; C07C211/49 ; C07C217/58 ; C07C219/28 ; C07C233/43 ; C07C235/20 ; C07C237/30 ; C07C255/24 ; C07C317/32 ; C07C323/32
摘要：
Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia′) or (Ib), as described herein.
公开/授权文献
- US20150191439A1 INHIBITORS TARGETING DRUG-RESISTANT INFLUENZA A 公开/授权日：2015-07-09
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