- 专利标题: 4,5-diarylimidazole derivatives as HDAC inhibitors
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申请号: US15326381申请日: 2015-07-13
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公开(公告)号: US09868750B2公开(公告)日: 2018-01-16
- 发明人: Michael Höpfner , Bernhard Biersack , Rainer Schobert , Katharina Mahal
- 申请人: CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN , UNIVERSITÄT BAYREUTH , Michael Höpfner , Bernhard Biersack , Rainer Schobert , Katharina Mahal
- 申请人地址: DE Berlin DE Bayreuth
- 专利权人: CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN,UNIVERSITÄT BAYREUTH
- 当前专利权人: CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN,UNIVERSITÄT BAYREUTH
- 当前专利权人地址: DE Berlin DE Bayreuth
- 代理机构: Lewis Roca Rothengerber Christie LLP
- 优先权: EP14177580 20140718
- 国际申请: PCT/EP2015/065948 WO 20150713
- 国际公布: WO2016/008836 WO 20160121
- 主分类号: C07F1/00
- IPC分类号: C07F1/00 ; C07D233/64
摘要:
The present invention relates to a 4,5-diarylimidazole derivative of formulae (I), (II) or (III): or a pharmaceutically acceptable salt thereof, wherein the 4,5-diarylimidazole derivative has a hydroxamic acid residue at a first aryl ring and a residue R1 at a second aryl ring; and wherein R1 is hydrogen, a halogen atom or an unsubstituted or substituted alkoxy group; R2 is independently selected from an unsubstituted or substituted alkyl, alkoxy or alkene group; M is a metal atom; L is a halogen atom, an unsubstituted or substituted phosphane, sulfane, arene or alkene group or a 4,5-diarylimidazole-derivative of formula (I); and n is an integer of from 1 to 5.
公开/授权文献
- US20170197992A1 4,5-DIARYLIMIDAZOLE DERIVATIVES AS HDAC INHIBITORS 公开/授权日:2017-07-13
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