Systems and methods for cancelling noise caused by the flicker of ambient lights are provided. Such noise cancelling systems and methods may be incorporated in a laser-based barcode scanning device. In one example, a barcode scanning device includes a light source, a first sensor, a second sensor, and a noise cancelling circuit. The light source is configured to emit a beam of light. The first sensor is configured to detect a first optical signal indicative of light reflecting off of a barcode. The reflected light may originate from the light source and from at least one ambient light source in the vicinity of the barcode scanning device. The second sensor is configured to detect a second optical signal indicative of light originating from the at least one ambient light source. The noise cancelling circuit is configured to obtain a noise-cancelled scanning signal from the first and second optical signals.