- 专利标题: Production of omega-amino fatty acids
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申请号: US14132473申请日: 2013-12-18
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公开(公告)号: US09719117B2公开(公告)日: 2017-08-01
- 发明人: Steffen Schaffer , Jasmin Gielen , Mirja Wessel , Hans-Georg Hennemann , Harald Haeger , Thomas Haas , Wilfried Bluemke
- 申请人: Steffen Schaffer , Jasmin Gielen , Mirja Wessel , Hans-Georg Hennemann , Harald Haeger , Thomas Haas , Wilfried Bluemke
- 申请人地址: DE Essen
- 专利权人: Evonik Degussa
- 当前专利权人: Evonik Degussa
- 当前专利权人地址: DE Essen
- 代理机构: Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权: EP12199024 20121221
- 主分类号: C12P13/00
- IPC分类号: C12P13/00 ; C12N9/12 ; C12N9/02 ; C12N9/06 ; C12N9/10
摘要:
The invention provides a whole cell catalyst which expresses a recombinant α-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase phosphopantetheinylating the fatty acid reductase, and which in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase expresses a transaminase, characterized in that the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and a method for the conversion of a fatty acid, ω-hydroxy fatty acid, ω-oxo fatty acid or a monoester thereof to an amine, comprising oxidation of the fatty acid, ω-hydroxy fatty acid, ω-oxo fatty acid or the monoester thereof to an oxidation product by contacting with an alkane hydroxylase and/or alcohol dehydrogenase, contacting the oxidation product with a phosphopantetheinylated fatty acid reductase or a α-dioxygenase to give an aldehyde, and contacting the aldehyde with a transaminase.
公开/授权文献
- US20140178948A1 PRODUCTION OF OMEGA-AMINO FATTY ACIDS 公开/授权日:2014-06-26
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