Invention Grant
- Patent Title: Dendritic cell vaccines for asparaginyl-β-hydroxylase expressing tumors
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Application No.: US12842494Application Date: 2010-07-23
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Publication No.: US09687537B2Publication Date: 2017-06-27
- Inventor: Masafumi Shimoda , Jack R. Wands
- Applicant: Masafumi Shimoda , Jack R. Wands
- Applicant Address: US RI Providence
- Assignee: Rhode Island Hospital
- Current Assignee: Rhode Island Hospital
- Current Assignee Address: US RI Providence
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ingrid A. Beattie
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K35/00 ; C12N5/0784 ; C12N9/02
Abstract:
A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
Public/Granted literature
- US20110076290A1 DENDRITIC CELL VACCINES FOR ASPARAGINYL-BETA-HYDROXYLASE EXPRESSING TUMORS Public/Granted day:2011-03-31
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