A system and method for autonomous dynamic spectrum assignment for operating and configuring a cellular wireless communication network, employing multiple Radio Access Technologies (RATs). The method consists of: partitioning the system radio frequency resources (spectrum) into fixed and pooled spectrum blocks; autonomously assigning pooled spectrum blocks at individual system access points or radio units or groups thereof; dynamically adapting the assignment of pooled spectrum blocks at individual system APs/RUs or groups of APs/RUs; implementation of the pooled block assignment function and integration with radio resource assignment functions of co-deployed RATs.