A method and apparatus for cancelling interference are disclosed. The method for cancelling interference, performed by a User Equipment (UE) includes receiving interference transmission layer restriction information about a neighbor Base Station (BS) transmitting an interference signal or information about the number of antenna ports used in transmitting the interference signal by the neighbor BS, detecting control information about the interference signal using the interference transmission layer restriction information, and removing the interference signal using the detected control information. The control information includes a field related to precoding of the interference signal determined differently according to a field related to Multiple User Multiple Input Multiple Output (MU-MIMO) included in the interference transmission layer restriction information, the information about the number of antenna ports, or the control information.