发明授权
US09593334B2 Use of the chromosome 19 microRNA cluster (C19MC) for treating viral disease and promoting authophagy
有权
使用染色体19微RNA簇（C19MC）治疗病毒性疾病和促进食管癌
- 专利标题： Use of the chromosome 19 microRNA cluster (C19MC) for treating viral disease and promoting authophagy
- 专利标题（中）： 使用染色体19微RNA簇（C19MC）治疗病毒性疾病和促进食管癌
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申请号： US14383222申请日： 2013-03-06
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公开(公告)号： US09593334B2公开(公告)日： 2017-03-14
- 发明人: Yoel Sadovsky , Carolyn Coyne Candrilli
- 申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 申请人地址： US PA Pittsburgh
- 专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Klarquist Sparkman, LLP
- 国际申请： PCT/US2013/029420 WO 20130306
- 国际公布： WO2013/134416 WO 20130912
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/113
摘要：
It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental recipient cells by exosome-mediated delivery of microRNAs (miRs). PHT cells express high levels of unique, primate-specific miRNAs, expressed from the chromosome 19 miRNA cluster (C19MC). It is further disclosed herein that C19MC miRNAs are packaged within PHT-derived exosomes and attenuate viral replication in recipient cells by inducing autophagy. Thus, provided herein are methods of inhibiting, treating or preventing microbial infections by administering one or more miRs of the C19MC. Also provided are methods of inducing autophagy in a cell by contacting the cell with one or more miRs of the C19MC.
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