发明授权
- 专利标题： Histidyl-tRNA synthetase-Fc conjugates
- 专利标题（中）： 组氨酰-tRNA合成酶-Fc偶联物
-
申请号： US14214491申请日： 2014-03-14
-
公开(公告)号： US09587235B2公开(公告)日： 2017-03-07
- 发明人: Ying Buechler , Kyle Chiang , Minh-Ha Do , Darin Lee , Kristi Piehl , Marc Thomas , Jeffry D. Watkins , Chi-Fang Wu , John D. Mendlein
- 申请人： aTyr Pharma Inc.
- 申请人地址： US CA San Diego
- 专利权人： aTyr Pharma, Inc.
- 当前专利权人： aTyr Pharma, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Cooley LLP
- 主分类号： C12N9/96
- IPC分类号： C12N9/96 ; C12N9/00
摘要：
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
公开/授权文献
- US20140349369A1 HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES 公开/授权日：2014-11-27
信息查询
