发明授权
US09586968B2 Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
有权
在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物
- 专利标题： Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
- 专利标题（中）： 在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物
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申请号： US15038805申请日： 2014-11-24
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公开(公告)号： US09586968B2公开(公告)日： 2017-03-07
- 发明人: Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
- 申请人： Merck Sharp & Dohme Corp. , Dansu Li , Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Xiu Wang , Xuanjia Peng
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 H. Eric Fischer; John C. Todaro
- 优先权： WOPCT/CN2013/001476 20131129
- 国际申请： PCT/US2014/067001 WO 20141124
- 国际公布： WO2015/080988 WO 20150604
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/407 ; C07D471/04 ; A61K31/4353 ; C07D491/20 ; C07D487/10 ; C07D277/52 ; C07D213/76 ; C07D239/42 ; C07D237/20 ; C07D285/135
摘要：
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
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