Techniques described herein are directed to performing back-end single-channel suppression of one or more types of interfering sources (e.g., additive noise) in an uplink path of a communication device. The back-end single-channel suppression techniques may suppress types(s) of additive noise using one or more suppression branches (e.g., a non-spatial (or stationary noise) branch, a spatial (or non-stationary noise) branch, a residual echo suppression branch, etc.). The non-spatial branch may be configured to suppress stationary noise from the single-channel audio signal, the spatial branch may be configured to suppress non-stationary noise from the single-channel audio signal and the residual echo suppression branch may be configured to suppress residual echo from the signal-channel audio signal. The spatial branch may be disabled based on an operational mode (e.g., single-user speakerphone mode or a conference speakerphone mode) of the communication device or based on a determination that spatial information is ambiguous.