发明授权
US09557327B2 DNA controlling miR-140 expression, and screening method of drugs using said DNA
有权
控制miR-140表达的DNA和使用所述DNA的药物筛选方法
- 专利标题： DNA controlling miR-140 expression, and screening method of drugs using said DNA
- 专利标题（中）： 控制miR-140表达的DNA和使用所述DNA的药物筛选方法
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申请号： US14388609申请日： 2013-04-02
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公开(公告)号： US09557327B2公开(公告)日： 2017-01-31
- 发明人: Hiroshi Asahara , Satoshi Yamashita , Mitsuru Naiki , Kentaro Abe
- 申请人： NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 申请人地址： JP Tokyo JP Osaka-shi
- 专利权人： NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人： NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： JP Tokyo JP Osaka-shi
- 代理机构： Oliff PLC
- 优先权： JP2012-084950 20120403
- 国际申请： PCT/JP2013/060111 WO 20130402
- 国际公布： WO2013/151058 WO 20131010
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; G01N33/53 ; C12N15/113 ; A01K67/027
摘要：
An object of the present invention is to provide DNA which regulates the expression of miR-140, a reporter vector which contains the DNA, cells and animals into which the reporter vector is introduced and a screening system for drugs which control the expression of miR-140 and is also to contribute in the development of new therapeutic agents for cartilage diseases such as osteoarthritis and intervertebral disk degeneration using the screening system. The DNA sequence according to the present invention is able to express any gene in a site where miR-140 is expressed and, in addition, it is also able to be utilized for screening a drug which regulates the expression of miR-140. Moreover, the drug that is selected by the screening system of the present invention is expected as a therapeutic agent for cartilage diseases accompanied by abnormality of cartilage.
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