发明授权
US09556273B2 Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
有权
抗巨噬细胞甘露糖受体单变量结构域用于肿瘤相关巨噬细胞的靶向和体内成像
- 专利标题： Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
- 专利标题（中）： 抗巨噬细胞甘露糖受体单变量结构域用于肿瘤相关巨噬细胞的靶向和体内成像
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申请号： US14402301申请日： 2013-03-15
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公开(公告)号： US09556273B2公开(公告)日： 2017-01-31
- 发明人: Jo Van Ginderachter , Patrick De Baetselier , Nick Devoogdt , Tony Lahoutte , Damya Laoui , Kiavash Movahedi , Geert Raes , Steve Schoonooghe
- 申请人： VIB VZW , Vrije Universiteit Brussel
- 申请人地址： BE Ghent BE Brussels
- 专利权人： VIB VZW,Vrije Universiteit Brussel
- 当前专利权人： VIB VZW,Vrije Universiteit Brussel
- 当前专利权人地址： BE Ghent BE Brussels
- 代理机构： TraskBritt, P.C.
- 国际申请： PCT/EP2013/055427 WO 20130315
- 国际公布： WO2013/174537 WO 20131128
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K51/10 ; A61K47/48 ; B82Y5/00
摘要：
The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
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