Invention Grant
- Patent Title: Double-acylated GLP-1 derivatives
- Patent Title (中): 双酰化GLP-1衍生物
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Application No.: US14101618Application Date: 2013-12-10
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Publication No.: US09556250B2Publication Date: 2017-01-31
- Inventor: Patrick William Garibay , Jane Spetzler , Lars Linderoth , Jesper Lau , Lauge Schaeffer
- Applicant: Novo Nordisk A/S
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Richard W. Bork
- Priority: EP09179390 20091216
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61K47/48 ; C07K14/65 ; A61K38/00 ; C07D233/64 ; C07K14/605

Abstract:
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K37, and the second K residue is designated K26, which derivative comprises two albumin binding moieties attached to K26 and K37, respectively, wherein the albumin binding moiety comprises a protracting moiety selected from:Chem. 1, Chem. 2, Chem. 3 or Chem. 4; or a pharmaceutically acceptable salt, amide, or ester thereof.
Public/Granted literature
- US20140179899A1 DOUBLE-ACYLATED GLP-1 DERIVATIVES Public/Granted day:2014-06-26
Information query
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