The disclosure generally relates to optimized always-on wireless service using network assistance and keep-alives. More particularly, in response to a user equipment (UE) requesting a bearer for an always-on service, a network may establish the bearer for the always-on service and transmit an availability time that indicates a period during which the bearer will be held in an active state to the UE. Any applications running on the UE may then use the bearer for the always-on service, and the UE may transmit a single keep-alive message to the network before the availability time expires to reset the period during which the bearer will be held in the active state. Furthermore, the keep-alive message may be structured to not generate a reply and thereby reduce battery consumption, reduce communication overhead, and improve network capacity.