发明授权
US09534014B2 Pharmaceutical compositions with attenuated release of phenolic opioids
有权
具有减轻酚类阿片样物质释放的药物组合物
- 专利标题： Pharmaceutical compositions with attenuated release of phenolic opioids
- 专利标题（中）： 具有减轻酚类阿片样物质释放的药物组合物
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申请号： US14320351申请日： 2014-06-30
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公开(公告)号： US09534014B2公开(公告)日： 2017-01-03
- 发明人: Thomas E. Jenkins , Julie D. Seroogy , Jonathan W. Wray
- 申请人： Signature Therapeutics, Inc.
- 申请人地址： US CA Palo Alto
- 专利权人： Signature Therapeutics, Inc.
- 当前专利权人： Signature Therapeutics, Inc.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Khin K. Chin; Carol L. Francis
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07K5/072 ; A61K31/155 ; A61K31/485 ; A61K31/135 ; A61K31/195 ; A61K31/439 ; A61K31/445 ; A61K31/451 ; A61K31/495 ; A61K31/55 ; A61K38/05 ; C07C215/64 ; C07C257/18 ; C07C279/18 ; C07D211/66 ; C07D217/04 ; C07D221/26 ; C07D223/04 ; C07D295/185 ; C07D491/08 ; A61K47/48
摘要：
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
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