A process for the production of books (22) with digital printing on a continuous paper strip (23), in which the strip defines book sections in sequence, with signature groups (33), each formed with basic sheets (34); the process employs a manufacturing system (21) which includes a transversal cutting equipment (41) for separating signature groups (33) as signatures sheets, and transversal and longitudinal folding equipment (46) for the formation of respective signatures (48); for a book with at least a sheet section devoid of text and/or figures in a last signature group, the method provides: a) identify a reduced signature group (59) including a number of sheet sections having at least a page with text and/or figures; b) cut the paper strip (23) to separate the reduced signature group as reduced signature group; c) actuate the transversal folding equipment (46) limited to the sheet sections having at least a page with text and/or figures and skipping the actuation of the transversal folding equipment (46) for a single sheet section; and d) actuate the longitudinal folding equipment (47) for folding longitudinally the reduced signature group.