Invention Grant
US09481714B2 Fusion proteins for use as immunogenic enhancers for inducing antigen-specific T cell responses
有权
用作诱导抗原特异性T细胞应答的免疫原性增强子的融合蛋白
- Patent Title: Fusion proteins for use as immunogenic enhancers for inducing antigen-specific T cell responses
- Patent Title (中): 用作诱导抗原特异性T细胞应答的免疫原性增强子的融合蛋白
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Application No.: US14095760Application Date: 2013-12-03
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Publication No.: US09481714B2Publication Date: 2016-11-01
- Inventor: Chia-Mao Wu , Hsiu-Kang Chang
- Applicant: TheVax Genetics Vaccine Co., Ltd.
- Applicant Address: TW Taipei
- Assignee: TheVax Genetics Vaccine Co., Ltd.
- Current Assignee: TheVax Genetics Vaccine Co., Ltd.
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/005 ; A61K39/21 ; A61K47/48 ; A61K39/385 ; C07K14/705 ; A61K39/12 ; A61K39/135 ; A61K39/17 ; C07K14/81 ; C12N9/10 ; C12N9/14 ; C07K14/21

Abstract:
A fusion protein for use as an immunogen enhancer for enhancing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen of a pathogen, wherein the APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen of the pathogen is located at the C-terminus of the protein transduction domain. The protein transduction domain is selected from the group consisting of: (i) a fusion polypeptide, comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide; (ii) a T cell-sensitizing signal-transducing peptide; and (iii) a translocation peptide of 34-112 amino acid residues in length.
Public/Granted literature
- US20140154285A1 FUSION PROTEINS FOR USE AS IMMUNOGENIC ENHANCERS FOR INDUCING ANTIGEN-SPECIFIC T CELL RESPONSES Public/Granted day:2014-06-05
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