Embodiments of the present invention relate to systems, devices and methods for translating I2C addresses. In accordance with an embodiment, a method for translating an I2C address includes receiving an original I2C address from a first I2C compatible device via an I2C-bus to which the first I2C compatible device is connected. The method also includes translating the original I2C address to a translated I2C address, and outputting the translated I2C address to a second I2C compatible device via a secondary side of the I2C-bus to which the slave device is connected. The original I2C address can be translated to the translated I2C address by subtracting an offset value from (or adding an offset value to) the original I2C address to produce the translated I2C address. Such an offset value can be specified using pin strapping, or by storing the offset value in a register or non-volatile memory that is programmable via the—I2C bus. Alternatively, a look-up-table, that is programmable via the I2C-bus, can be used to perform the I2C address translation.