Image restoration cascades are described, for example, where digital photographs containing noise are restored using a cascade formed from a plurality of layers of trained machine learning predictors connected in series. For example, noise may be from sensor noise, motion blur, dust, optical low pass filtering, chromatic aberration, compression and quantization artifacts, down sampling or other sources. For example, given a noisy image, each trained machine learning predictor produces an output image which is a restored version of the noisy input image; each trained machine learning predictor in a given internal layer of the cascade also takes input from the previous layer in the cascade. In various examples, a loss function expressing dissimilarity between input and output images of each trained machine learning predictor is directly minimized during training. In various examples, data partitioning is used to partition a training data set to facilitate generalization.