- 专利标题： Tubulysin compounds, methods of making and use
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申请号： US14605549申请日： 2015-01-26
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公开(公告)号： US09382289B2公开(公告)日： 2016-07-05
- 发明人: Qiang Cong , Heng Cheng , Sanjeev Gangwar
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Yuan Chao
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K5/117 ; A61K47/48 ; C07K7/06 ; C07K5/10 ; A61K38/07 ; C07K5/06 ; C07K5/078 ; A61K38/05 ; C07K5/107
摘要：
Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
公开/授权文献
- US20150132324A1 TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE 公开/授权日：2015-05-14
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