发明授权
US09334274B2 N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
有权
吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂
![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/docs/US/2016-05-10/US09334274B2/abs.jpg.600x600.jpg)
- 专利标题： N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
- 专利标题（中）： 吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂
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申请号： US14250843申请日： 2014-04-11
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公开(公告)号： US09334274B2公开(公告)日： 2016-05-10
- 发明人: James D Rodgers , Stacey Shepard , Argyrios G Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Wenyu Zhu , Joseph Glenn , Lixin Shao
- 申请人： Incyte Corporation , Incyte Holdings Corporation
- 申请人地址： US DE Wilmington US DE Wilmington
- 专利权人： Incyte Holdings Corporation,Incyte Corporation
- 当前专利权人： Incyte Holdings Corporation,Incyte Corporation
- 当前专利权人地址： US DE Wilmington US DE Wilmington
- 代理机构： Fish & Richardson P.C.
- 主分类号： A01N43/90
- IPC分类号： A01N43/90 ; A61K31/519 ; C07D487/00 ; C07D487/04 ; C07D519/00 ; C07D471/04 ; C07D491/048 ; C07D495/04 ; C07D498/04 ; C07D513/04
![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/abs-image/US/2016/05/10/US09334274B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
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