发明授权
US09290740B2 Use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells
有权
碱性成纤维细胞生长因子在动物结缔组织细胞去分化中的应用
- 专利标题： Use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells
- 专利标题（中）： 碱性成纤维细胞生长因子在动物结缔组织细胞去分化中的应用
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申请号： US12921128申请日： 2009-03-09
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公开(公告)号： US09290740B2公开(公告)日： 2016-03-22
- 发明人: Raymond L. Page , Tanja Dominko
- 申请人： Raymond L. Page , Tanja Dominko
- 申请人地址： US MA Worcester
- 专利权人： Worcester Polytechnic Institute
- 当前专利权人： Worcester Polytechnic Institute
- 当前专利权人地址： US MA Worcester
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请： PCT/US2009/001517 WO 20090309
- 国际公布： WO2009/111087 WO 20090911
- 主分类号： A61K9/70
- IPC分类号： A61K9/70 ; A61P7/00 ; A61P35/00 ; A61P3/10 ; A61P25/28 ; A61K35/12 ; A61P1/16 ; C12N5/071 ; C12N5/077 ; A61P25/00 ; A61P19/08 ; C12N5/0775
摘要：
De-differentiation protocols are described herein for generating progenitor cells from adult connective tissue, in particular adult human fibroblasts. The de-differentiation protocols described herein comprise culturing the differentiated cells with an amount of FGF2 to de-differentiate the cells. These de-differentiated cells may then be cultured and used for experimentation, amplification and clinical applications. The clinical applications include the use of the cells for tissue and cell based therapies.
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